Rituximab Structure

Description rituximab is a genetically engineered chimeric murinehuman monoclonal antibody directed against the cd20 antigen found on the surface of normal and malignant b lymphocytes.

Rituximab structure. The rcsb pdb also provides a variety of tools and resources. Rituximab was developed by researcher nabil hanna and coworkers at idec pharmaceuticals under the name idec c2b8. Patent for the drug was issued in 1998 and expired in 2015. Rituximab binds to amino acids 170 173 and 182 185 on cd20 which are physically close to each other as a result of a disulfide bond between amino acids 167 and 183.

To understand the molecular mechanism of recognition of human cd20 by rituximab we determined the crystal structure of the rituximab fab in complex with a synthesized peptide comprising the cd20 epitope residues 163 187 at 26 a resolution. These molecules are visualized downloaded and analyzed by users who range from students to specialized scientists. Binding regions from original murine anti human cd20 consisting of variable regions of immunoglobulin heavy and light chains are fused to human igg1 heavy chain and. Patients with cancer who take rituximab intravenous may be at a greater risk of getting a severe health problem called tumor lysis syndrome tlsthis may lead to death.

Rituximab ri tux i mab is a human mouse chimeric monoclonal immunoglobulin g1 antibody to the cell surface antigen cd20 also known as human b lymphocyte restricted differentiation antigen. Dosage can vary depending on the desired treatment. Users can perform simple and advanced searches based on annotations relating to sequence structure and function. As a member of the wwpdb the rcsb pdb curates and annotates pdb data according to agreed upon standards.

Some side effects may occur during the injection or within 24 hours afterward. The antibody is an igg1 kappa immunoglobulin containing murine light and heavy chain variable region sequences and human constant region sequences 6 label. If you used rituximab intravenous when you were pregnant tell your babys doctor. Rituximab is a liquid drug that is administered into patients veins.

Get emergency medical help if you have signs of an allergic reaction hives difficult breathing swelling in your face or throat or a severe skin reaction fever sore throat burning eyes skin pain red or purple skin rash with blistering and peeling. Rituximab is a chimeric monoclonal antibody of the immunoglobulin g1 igg1 sub class comprising a murine variable region fab region and a human constant region fc region.